Species and Tissue Differences in β-Estradiol 17-Glucuronidation
نویسندگان
چکیده
منابع مشابه
Chronic estradiol - 17 β exposure increases superoxide production in the
1 Women are exposed to estrogen in several forms such as oral contraceptive pills and 2 hormone replacement therapy. Although estrogen was believed to be cardioprotective, 3 lately, its beneficial effects are being questioned. Recent studies indicate that oxidative 4 stress in the rostral ventrolateral medulla (RVLM) may play a role in the development of 5 hypertension. Therefore, we hypothesiz...
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Background & Aims: Adult neurogenesis occurs in the two main areas of the brain of most mammalian species in; sub ventricular zone, and the dentate gyrus of the hippocampus. Many factors such as 17-β estradiol affect neurogenesis in the hippocampus. The aim of this study was to investigate the effect of exogenous 17-β estradiol on neurogenesis in the ovariectomized (OVX) mice. Materials & Meth...
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Glucuronidation of amines has been shown to exhibit species differences in vitro and in vivo. Substrates for N-glucuronidation can be classified according to the chemical structures of the resulting glucuronides into two groups: compounds that form nonquaternary N-conjugates, and those that form the quaternary counterparts. For compounds of the former class—such as sulfonamides, arylamines, and...
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PURPOSE To elucidate the mechanism of 17-β estradiol (17β-E(2))-mediated protection of retinal pigment epithelium (RPE) from oxidative stress. METHODS Cultured ARPE-19 cells were subjected to oxidative stress with t-butyl hydroxide or hydrogen peroxide in the presence or absence of 17β-E(2). Reactive oxygen species (ROS) were measured using H(2)DCFDA fluorescence. Apoptosis was evaluated by c...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2017
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b17-00365